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Review
. 2018 May;36(2):339-353.
doi: 10.1016/j.ncl.2018.01.006.

Measuring Clinical Treatment Response in Myasthenia Gravis

Carolina Barnett  1 , Laura Herbelin  2 , Mazen M Dimachkie  2 , Richard J Barohn  2
Affiliations
Review

Measuring Clinical Treatment Response in Myasthenia Gravis

Carolina Barnett et al. Neurol Clin. 2018 May.

Abstract

In this article we provide an overview of health-related outcome measurement-to better understand what different outcomes used in myasthenia actually measure-and to provide some guidance when choosing measures based on the clinical context and question. In myasthenia, the most commonly used outcome measures are aimed at assessing the signs and symptoms. In this review, we provide a summary of the most commonly used outcome measures. We discuss instruments that gauge disease overall health impact, such as on disability and quality of life. Finally, we discuss other relevant outcomes such as steroid-sparing effects and the role of surrogate markers.

Keywords: Disability; Minimal important difference; Myasthenia gravis; Outcome measurement; Responsiveness.

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Figures

Fig. 1.
Fig. 1.
Commonly Used myasthenia gravis (MG) outcomes in relation to the International Classification of Functioning, Disability and Health (ICF). The ICF framework (within the red box) and which aspects of the disease are measured by commonly used MG measures. Measures of health-related quality of life (HRQoL) also incorporate mental health and overall wellbeing. INCB-MG, Besta Neurologic Institute rating scale for MG; MG-ADL, Myasthenia Gravis Activities of Daily Living; MGC, Myasthenia Gravis Composite; MG-DIS, MG Disability Scale; MGII, Myasthenia Gravis Impairment Index; MMT, Manual Muscle Test; QMGS, Quantitative Myasthenia Gravis Score. (Modified from World Health Organization. International classification of functioning, disability and health (ICF). 1st edition. Geneva: World Health Organization; 2002.)
See this image and copyright information in PMC

References

    1. Jette AM. Toward a common language for function, disability, and health. Phys Ther 2006;86(5):726–34. - PubMed
    1. World Health Organization. International classification of functioning, disability and health (ICF) 1st edition. Geneva: World Health Organization; 2002. Available at: http://www.who.int/classifications/icf/icfbeginnersguide.pdf?ua=1. Accessed June, 2017.
    1. Guyatt GH, Bombardier C, Tugwell PX. Measuring disease-specific quality of life in clinical trials. Can Med Assoc J 1986;134:889. - PMC - PubMed
    1. Kirshner B, Guyatt G. A methodological framework for assessing health indices. J Chronic Dis 1985;38(1):27–36. - PubMed
    1. King MT. A point of minimal important difference (MID): a critique of terminology and methods. Expert Rev Pharmacoecon Outcomes Res 2011;11(2):171–84. - PubMed

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