Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov;1862(11):2506-2510.
doi: 10.1016/j.bbagen.2018.04.011. Epub 2018 Apr 12.

Molecular mechanism of selenoprotein P synthesis

Sumangala Shetty  1 , Paul R Copeland  2
Affiliations
Review

Molecular mechanism of selenoprotein P synthesis

Sumangala Shetty et al. Biochim Biophys Acta Gen Subj. 2018 Nov.

Abstract

Background: Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalian selenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events.

Scope of review: In this review we elaborate on new data and current models that provide insight into how SELENOP is made.

Major conclusions: SELENOP synthesis requires a specific set of factors and conditions.

General significance: As the key protein required for proper selenium distribution, SELENOP stands out as a lynchpin selenoprotein that is essential for male fertility, proper neurologic function and selenium metabolism.

Keywords: SBP2; SECIS; SECISBP2L; Selenium; Selenocysteine; Selenoprotein P.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A) Schematic representation of rat SELENOP cDNA. Vertical lines represent Sec codons. On the 3′ end is the native SELENOP 3′UTR with SECIS-1 and 2. B) Nucleotide alignment (Clustal W) of SELENOP coding region in vertebrates. Black represents >80% identity, grey represents >60% identity and the 80% identity, grey represents >60% identity and
See this image and copyright information in PMC

References

    1. Copeland PR, Fletcher JE, Carlson BA, Hatfield DL, Driscoll DM. A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. EMBO J. 2000;19:306–314. - PMC - PubMed
    1. Tujebajeva RM, Copeland PR, Xu XM, Carlson BA, Harney JW, Driscoll DM, Hatfield DL, Berry MJ. Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Rep. 2000;1:158–163. - PMC - PubMed
    1. Fagegaltier D, Hubert N, Yamada K, Mizutani T, Carbon P, Krol A. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. EMBO J. 2000;19:4796–4805. - PMC - PubMed
    1. Gupta N, Demong LW, Banda S, Copeland PR. Reconstitution of selenocysteine incorporation reveals intrinsic regulation by SECIS elements. J Mol Biol. 2013;425:2415–2422. - PMC - PubMed
    1. Bösl MR, Takaku K, Oshima M, Nishimura S, Taketo MM. Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp) Proc Natl Acad Sci U S A. 1997;94:5531–5534. - PMC - PubMed