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. 2018;7(1):282.
doi: 10.4172/2167-0277.1000282. Epub 2018 Feb 12.

Obstructive Sleep Apnea as a Risk Factor for Atrial Fibrillation: A Meta-Analysis

Irini Youssef  1 , Haroon Kamran  1 , Mena Yacoub  2 , Nirav Patel  3 , Clive Goulbourne  1 , Shweta Kumar  1 , Jesse Kane  1 , Haley Hoffner  1 , Moro Salifu  1 , Samy I McFarlane  1
Affiliations

Obstructive Sleep Apnea as a Risk Factor for Atrial Fibrillation: A Meta-Analysis

Irini Youssef et al. J Sleep Disord Ther. 2018.

Abstract

Objectives: To conducted a meta-analysis assessing the relationship between Obstructive Sleep Apnea (OSA) and the risk of Atrial Fibrillation (AF).

Methods: We searched PUBMED, Medline, and Cochrane Library using the keywords "atrial fibrillation", "obstructive sleep apnea" and "sleep disordered breathing (SDB)". All subjects included had established diagnosis of OSA/SDB. We then compared the occurrence of AF versus no AF. Analysis done with Comprehensive Meta-Analysis package V3 (Biostat, USA).

Results: A total of 579 results were generated. Duplicates were removed and 372 records were excluded based on irrelevant abstracts, titles, study design not consistent with the stated outcome, or full-text unavailable. Twelve studies meeting the inclusion criteria were reviewed in full-text; 2 of these articles were eventually removed due to unconfirmed OSA diagnostic modality, and one was also removed based on a control group inconsistent with the other studies. Therefore, a total of 9 studies were included (n=19,837). Sample sizes ranged from n=160 patients to n=6841 patients. The risk of AF was found to be higher among OSA/SDB versus control group (OR; 2.120, C.I: 1.845-2.436, Z; 10.598 p: <0.001). The heterogeneity observed for the pooled analysis was Q-value; 22.487 df (Q); 8 P-value; 0.004, I-squared; 64.424 Tau2; 0.098, suggesting appropriate study selection and moderate heterogeneity.

Conclusion: OSA/SDB is strongly associated with AFib confirming the notion that OSA/SDB populations are high risk for development of AF. Prospective studies are needed to ascertain the effect of the treatment of OSA/SDB for the prevention of AF, a growing health burden with serious consequences.

Keywords: Atrial Fibrillation; Cardiac arrhythmias; Health; Meta-analysis; Sleep Apnea.

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Figures

Figure 1
Figure 1
Flow diagram explaining the process of selections of the studies included in our meta-analysis.
Figure 2
Figure 2
Forrest plot depicting the odds ratio of having AFIB associated with OSA.
See this image and copyright information in PMC

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