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Randomized Controlled Trial
. 2017 Feb;23(2):169-172.

[Ningmitai Capsules combined with doxycycline hydrochloride for Ureaplasma urealyticumpositive chronic prostatitis]

[Article in Chinese]
Li-Hua Li  1 , Xun-Bin Huang  1 , Hui-Ping Zhang  1 , Dun-Zhen Xiao  1 , Jing-Song Chai  1 , Zhen Ye  1
Affiliations
  • PMID: 29658257
Randomized Controlled Trial

[Ningmitai Capsules combined with doxycycline hydrochloride for Ureaplasma urealyticumpositive chronic prostatitis]

[Article in Chinese]
Li-Hua Li et al. Zhonghua Nan Ke Xue. 2017 Feb.

Abstract
in English, Chinese

Objective: To investigate the effects of Ningmitai Capsules (NMT) combined with doxycycline hydrochloride (DH) on chronic prostatitis induced by Ureaplasma urealyticum (Uu).

Methods: This randomized controlled trial included 240 male patients with Uupositive chronic prostatitis, treated orally with NMT at 4 capsules tid (n= 35), DH at 100 mg bid (n = 78), and NMT+DH at the corresponding doses (n = 127), respectively, all for 2 successive weeks. At 1 week after drug withdrawl, we conducted routine urine analysis, EPS examination, and drug sensitivity test of the cultured Uu.

Results: The positivetonegative rate of Uu was significantly higher in the NMT+DH group than in the NMT and DH groups (89.0% ［113/127］ vs 54.3% ［19/35］ and 71.8% ［56/78］, P< 0.05), so were the cure rate (25.2% vs 20.0% and 20.5%, P< 0.05) and total effectiveness rate (89.0% vs 54.3% and 71.8%, P< 0.05).

Conclusions: The combination of Ningmitai Capsules and doxycycline hydrochloride is more effective than either Ningmitai Capsules or doxycycline hydrochloride used alone in the treatment of Uupositive chronic prostatitis.

目的: 观察宁泌泰胶囊联合盐酸多西环素片对溶脲脲原体(Uu)引起的慢性前列腺炎的疗效。方法: 采用随机对照研究方法，选取Uu阳性的慢性前列腺炎患者240例，随机分为中药组(35例)、西药组(78例)和联合组(127例)，连续用药2周，观察临床疗效。中药组口服宁泌泰胶囊，4粒/次，3次/日；西药组口服盐酸多西环素片，100 mg/次，2次/日；联合组口服宁泌泰胶囊，4粒/次，3次/日，并联用盐酸多西环素片，100 mg/次，2次/日。结果： 中药组、西药组和联合组Uu转阴率分别为54.3%（19/35），71.8%（56/78）和89.0%（113/127），联合组明显高于中、西药组（P均< 0.05）。联合组、西药组和中药组的治愈率分别为25.2%、20.5%和20.0%，总有效率分别为89.0%、71.8%和54.3%，联合组与中药组比较差异具有统计学意义（P < 0.05）。结论: 宁泌泰胶囊联合盐酸多西环素片治疗Uu阳性的慢性前列腺炎比单用宁泌泰胶囊或盐酸多西环素片疗效好。.

Keywords: Ningmitai Capsules; Ureaplasma urealyticum; chronic prostatitis; doxycycline hydrochloride; drug combination.

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