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. 1988 Jan-Feb;8(1):187-90.

Growth inhibitory effect of LH-RH analogs on human breast cancer cells

G Scambia  1 , P B Panici, G Baiocchi, L Perrone, C Gaggini, S Iacobelli, S Mancuso
Affiliations
  • PMID: 2965864

Growth inhibitory effect of LH-RH analogs on human breast cancer cells

G Scambia et al. Anticancer Res. 1988 Jan-Feb.

Abstract

The antiproliferative effect of two LH-RH agonists (Pro 9-LH-RH ethylamide and D Ser(t BU)6 Aza Gly 10-LH-RH, ICI 118630) on the human breast cancer cell line CG5 is reported. Although ineffective when used alone, both analogs inhibited in a dose-dependent fashion the growth stimulatory effect of estradiol. LH-RH analogs did not influence the growth inhibitory effect of tamoxifen and medroxyprogesterone acetate. Likewise, these compounds neither modified basal estrogen and progesterone receptor levels nor prevented estrogen-induced increase of progesterone receptor. A marked antiproliferative effect of the analogs was also seen in cells stimulated with other mitogens, such as insulin and epidermal growth factor.

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