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. 2018 Apr;7(2):CNS17.
doi: 10.2217/cns-2017-0030. Epub 2018 Apr 16.

The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review

Kirsty J Martin-McGill  1 , Nisaharan Srikandarajah  1 , Anthony G Marson  1 , Catrin Tudur Smith  2 , Michael D Jenkinson  1
Affiliations

The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review

Kirsty J Martin-McGill et al. CNS Oncol. 2018 Apr.

Abstract

Aim: We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas.

Methods: The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors.

Results: No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias. All studies reported overall or progression-free survival; however the effectiveness of KD interventions could not be established. Dietary acceptability was not reported.

Conclusion: The effectiveness and acceptability of KDs in the management of gliomas is unknown and high quality randomized controlled trials are needed.

Keywords: glioblastoma; glioma; ketogenic diet; systematic review.

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Conflict of interest statement

Financial & competing interests disclosure

MD Jenkinson, AG Marson, C Tudur Smith, KJ Martin-McGill receive funding from Vitaflo (International) Ltd for KJ Martin-McGill PhD studies. However, Vitaflo did not contribute to or influence this review. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Writing assistance was utilized in the production of this manuscript – funded by Vitaflo (International) Ltd.

Figures

<b>Figure 1.</b>
Figure 1.. PRISMA flow diagram.
Adapted with permission from [8] Moher et al. (2009).
See this image and copyright information in PMC

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