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Case Reports
. 2018 Jul;43(7):526-528.
doi: 10.1097/RLU.0000000000002100.

Loss of PSMA Expression in Non-neuroendocrine Dedifferentiated Acinar Prostate Cancer

Peter Bronsert, Kathrin Reichel, Juri Ruf
Case Reports

Loss of PSMA Expression in Non-neuroendocrine Dedifferentiated Acinar Prostate Cancer

Peter Bronsert et al. Clin Nucl Med. 2018 Jul.

Abstract

The introduction of tracers targeting the prostate-specific membrane antigen (PSMA) has revolutionized PET imaging of acinar prostate adenocarcinoma. In general, an increasing PSMA expression is assumed with increasing dedifferentiation. Whereas loss of PSMA expression has been reported in case of neuroendocrine dedifferentiation, we present a patient with acinar prostate adenocarcinoma with a loss of PSMA expression after chemotherapy on PET/CT and in histological and immunohistochemical analyses. All tissue samples indicated the retention of acinar features but no expression of neuroendocrine markers (NSE, synaptophysin, chromogranin, and CD56), corresponding to nonelevated serum NSE.

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