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. 2018 Jul 24;218(5):757-767.
doi: 10.1093/infdis/jiy204.

Household Transmission of Ebola Virus: Risks and Preventive Factors, Freetown, Sierra Leone, 2015

Mary R Reichler  1 , James Bangura  2 , Dana Bruden  3 , Charles Keimbe  2 , Nadia Duffy  4 , Harold Thomas  2 , Barbara Knust  5 , Ishmail Farmar  2 , Erin Nichols  6 , Amara Jambai  2 , Oliver Morgan  7 , Thomas Hennessy  3 ; Household Transmission Investigative Team
Collaborators, Affiliations

Household Transmission of Ebola Virus: Risks and Preventive Factors, Freetown, Sierra Leone, 2015

Mary R Reichler et al. J Infect Dis. .

Abstract

Background: Knowing risk factors for household transmission of Ebola virus is important to guide preventive measures during Ebola outbreaks.

Methods: We enrolled all confirmed persons with Ebola who were the first case in a household, December 2014-April 2015, in Freetown, Sierra Leone, and their household contacts. Cases and contacts were interviewed, contacts followed prospectively through the 21-day incubation period, and secondary cases confirmed by laboratory testing.

Results: We enrolled 150 index Ebola cases and 838 contacts; 83 (9.9%) contacts developed Ebola during 21-day follow-up. In multivariable analysis, risk factors for transmission included index case death in the household, Ebola symptoms but no reported fever, age <20 years, more days with wet symptoms; and providing care to the index case (P < .01 for each). Protective factors included avoiding the index case after illness onset and a piped household drinking water source (P < .01 for each).

Conclusions: To reduce Ebola transmission, communities should rapidly identify and follow-up all household contacts; isolate those with Ebola symptoms, including those without reported fever; and consider closer monitoring of contacts who provided care to cases. Households could consider efforts to minimize risk by designating one care provider for ill persons with all others avoiding the suspected case.

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Conflict of interest statement

Potential conflicts of interest. All authors report no potential conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Epidemic curve of study enrollment compared with Western District, Sierra Leone Ebola outbreak, 2014–2015.
See this image and copyright information in PMC

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