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. 2018 Jun 26;62(7):e00091-18.
doi: 10.1128/AAC.00091-18. Print 2018 Jul.

Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes

M Angeles Argudín  1 , S Roisin  2 , L Nienhaus  2 , M Dodémont  2 , R de Mendonça  2 , C Nonhoff  2 , A Deplano  2 , O Denis  2   3
Affiliations

Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes

M Angeles Argudín et al. Antimicrob Agents Chemother. .

Abstract

Methicillin-resistant Staphylococcus aureus isolates lacking mec genes (n = 32), collected from Belgian hospitals, were characterized for their β-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpP and yjbH). Twelve isolates were β-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.

Keywords: BORSA; MODSA; PBP; β-lactamase.

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