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. 2018 Apr 11;16(2):1559325818761455.
doi: 10.1177/1559325818761455. eCollection 2018 Apr-Jun.

The Neuroprotective Effects of Thymoquinone: A Review

Tahereh Farkhondeh  1 , Saeed Samarghandian  2 , Ali Mohammad Pourbagher Shahri  3 , Fariborz Samini  4
Affiliations

The Neuroprotective Effects of Thymoquinone: A Review

Tahereh Farkhondeh et al. Dose Response. .

Abstract

Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on. In addition, TQ protected brain cells from various injuries due to its antioxidant, anti-inflammatory, and apoptotic effects in cell line and experimental animal models. The present study has been designed to review the scientific literature about the pharmacological activities of TQ to the neurological diseases. This study purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects.

Keywords: anti-inflammation; antioxidant; apoptosis; neurodegenerative diseases; thymoquinone.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflict of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Dubick MA. Historical perspectives on the use of herbal preparations to promote health. J Nutr. 1986;116(7):1348–1354. - PubMed
    1. Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med. 2009;15(6):639–644. - PubMed
    1. Gali-Muhtasib H, El-Najjar N, Schneider-Stock R. The medicinal potential of black seed (Nigella sativa) and its components. Adv Phytomedicine. 2006;2:133–153.
    1. Ahmad A, Husain A, Mujeeb M, et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337–352. - PMC - PubMed
    1. Taborsky J, Kunt M, Kloucek P, Lachman J, Zeleny V, Kokoska L. Identification of potential sources of thymoquinone and related compounds in Asteraceae, Cupressaceae, Lamiaceae, and Ranunculaceae families. Open Chem. 2012;10(6):1899–1906.

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