Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb 14:2018:8398156.
doi: 10.1155/2018/8398156. eCollection 2018.

Analysis of the Clinicopathological Characteristics and Risk Factors in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease

Jian-Long Miao  1 , Jing-Jing Cai  1 , Xiao-Feng Qin  2 , Rui-Juan Liu  1
Affiliations

Analysis of the Clinicopathological Characteristics and Risk Factors in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease

Jian-Long Miao et al. Biomed Res Int. .

Abstract

Objective: To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD.

Materials and methods: We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smoking status, and histologic type was obtained from medical records.

Results: Lung cancer patients with COPD and those with the chronic bronchitis (CB) phenotype had higher smoking indices compared to those without COPD (723.95 ± 631.48 and 920.95 ± 712.93 versus 418.40 ± 506.84; P = 0.010; P = 0.001, resp.), and current smokers accounted for significantly higher proportions of lung cancer patients with COPD and the CB phenotype versus without COPD (51.15% and 63.74% versus 35.19%; P = 0.009; P = 0.001, resp.). Adenocarcinoma was significantly more common in lung cancer patients without versus with COPD (48.15% versus 35.63%; P = 0.037), whereas small cell lung cancer was more common in patients with COPD (23.56% versus 13.89%). Among patients with COPD, male sex (odds ratio [OR], 19.946; P < 0.001), current smokers (OR: 6.588; P = 0.001), and age ≥ 75 years (OR: 2.670; P = 0.008) were identified as high-risk factors.

Conclusion: The risk factors for COPD among lung cancer patients were age ≥ 75 years, current smokers with the CB phenotype, and male sex.

PubMed Disclaimer

References

    1. Ferlay J., Soerjomataram I., Dikshit R., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2014 doi: 10.1002/ijc.29210. - DOI - PubMed
    1. Früh M., de Ruysscher D., Popat S., Crinò L., Peters S., Felip E. Small-cell lung cancer (SCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2013;24(supplement 6):vi99–vi105. doi: 10.1093/annonc/mdt178. - DOI - PubMed
    1. Kalemkerian G. P., Gadgeel S. M. Modern staging of small cell lung cancer. Journal of the National Comprehensive Cancer Network. 2013;11(1):78–98. doi: 10.6004/jnccn.2013.0012. - DOI - PubMed
    1. Walser T., Cui X., Yanagawa J., et al. Smoking and lung cancer: The role of inflammation. Proceedings of the American Thoracic Society. 2008;5(8):811–815. doi: 10.1513/pats.200809-100TH. - DOI - PMC - PubMed
    1. Takahashi H., Ogata H., Nishigaki R., Broide D. H., Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKβ- and JNK1-dependent inflammation. Cancer Cell. 2010;17(1):89–97. doi: 10.1016/j.ccr.2009.12.008. - DOI - PMC - PubMed

LinkOut - more resources