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Case Reports
. 2018 May;24(5):939-941.
doi: 10.3201/eid2405.171763.

Cerebrospinal Fluid Immunoglobulins as Potential Biomarkers of Chikungunya Encephalitis

Marzia Puccioni-Sohler, Luiz Claudio Farias, Mauro Jorge Cabral-Castro, Mariano G Zalis, Rosangela S Kalil, Maria Cecília F Salgado
Case Reports

Cerebrospinal Fluid Immunoglobulins as Potential Biomarkers of Chikungunya Encephalitis

Marzia Puccioni-Sohler et al. Emerg Infect Dis. 2018 May.

Abstract

Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.

Keywords: CHIKV; IgG; IgM; alphavirus; cerebrospinal fluid; chikungunya virus; humoral immune response; immunoglobulins; meningitis/encephalitis; vector-borne infections; viruses.

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