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. 1988 Apr;20(2 Suppl 2):115-21.

Immunosuppressive effect of cyclosporine metabolites from human bile on alloreactive T cells

A Zeevi  1 , G Eiras, G Burckart, L Makowka, R Venkataramanan, C P Wang, D H Van Thiel, N Murase, T E Starzl, R Duquesnoy
Affiliations

Immunosuppressive effect of cyclosporine metabolites from human bile on alloreactive T cells

A Zeevi et al. Transplant Proc. 1988 Apr.
No abstract available

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Figures

Fig 1
Fig 1
Effect of CsA and its bile-derived metabolites on MLR response cpm background. (A) Dose effect of CsA and metabolites M17, M1, M21, M13, and fraction 4. (B) Inhibition of MLR response in the presence of 5 μg/mL of CsA metabolite fractions. MLR response was 23,168 ± 1,335 cpm.
Fig 2
Fig 2
Dose effect of CsA on PLT response of alloreactive T cell clones HA6 and DB29. PLT response of clones HA6 12,069 ± 1,301 and DB29 25377 ± 1,376.
Fig 3
Fig 3
Effect of 5 μg/mL of CsA metabolites on PLT activity of alioreactive T cell clones HA6 and DB29. For PLT response see Fig 2 legend.
Fig 4
Fig 4
Dose effect of CsA end metabolites M17, M1, M18, and M21 on PLT response of lymphocytes propagated from an LB. The donor-specific PLT response of LB cells was 20,330 ± 1,507 cpm.
Fig 5
Fig 5
Dose effect of CsA and metabolites M17, M21, and M18 on donor-specific PLT activity of HB-grown lymphocytes. The PLT response of HB culture was 60,900 ± 2,913 cpm.
Fig 6
Fig 6
Inhibition of PLT reactivity of four lymphocyte cultures propagated from sequential HBs HB1, HB2, HB3, and HB4 in the presence of (A) CsA and (B) M17. Donor-specific PLT responses of these HB lymphocytes were: HB1, 19.850 ± 2,024 cpm; HB2, 11,504 ± 412 cpm; HB3, 43,750 ± 705 cpm; HB4, 13,053 ± 872 cpm.
Fig 7
Fig 7
Effect of combination of low doses of CsA and M17 on PLT response of activated T cell propagated from a heart biopsy. Donor-specific PLT response 60,900 ± 2,913 cpm.
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References

    1. Maurer G, Loosli HR, Schreier E, et al. Drug Metab Dispos. 1984;12:120. - PubMed
    1. Wood AJ, Maurer G, Niederberger W, et al. Transplant Proc. 1983;15:193.
    1. Venkataramanan R, Starzl TE, Yang S, et al. Transplant Proc. 1985;17:286. - PMC - PubMed
    1. Burckart GJ, Starzl TE, Venkataramanan R, et al. Transplant Proc. 1986;18:46. - PMC - PubMed
    1. Rosano TG, Freed BM, Cerilli J, et al. Transplantation. 1986;42:262. - PubMed

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