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. 1988 Apr;20(2 Suppl 2):51-7.

A study of the correlation between cyclophilin binding and in vitro immunosuppressive activity of cyclosporine A and analogues

P L Durette  1 , J Boger, F Dumont, R Firestone, R A Frankshun, S L Koprak, C S Lin, M R Melino, A A Pessolano, J Pisano, et al.
Affiliations
  • PMID: 2966482

A study of the correlation between cyclophilin binding and in vitro immunosuppressive activity of cyclosporine A and analogues

P L Durette et al. Transplant Proc. 1988 Apr.

Abstract

In order to establish whether CyP is the pharmacologically relevant CsA receptor, the CyP binding v immunosuppressive activity was measured for an extensive, structurally varied group of CsA analogues. Overall, CyP binding was found to parallel immunosuppressive activity. Other than MeAla6-CsA, the few exceptions to the correlation could be ascribed to cellular metabolism. These results strongly implicate CyP or a related protein in the mechanism of action of cyclosporine.

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