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. 2019 Oct;28(5):521-531.
doi: 10.1017/S2045796018000185. Epub 2018 Apr 18.

Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study

L Vizzini  1 , M Popovic  1 , D Zugna  1 , B Vitiello  2 , M Trevisan  1 , C Pizzi  1 , F Rusconi  3 , L Gagliardi  4 , F Merletti  1 , L Richiardi  1
Affiliations

Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study

L Vizzini et al. Epidemiol Psychiatr Sci. 2019 Oct.

Abstract

Aims.: Maternal mental disorders have been associated with the risk of attention-deficit/hyperactivity disorder (ADHD) in children. Within the context of a mother-child cohort, we examined whether maternal anxiety, depression and sleep disorders are associated with pre-school ADHD symptoms.

Methods.: The study included 3634 singletons from the Italian NINFEA (Nascita e INFanzia: gli Effetti dell'Ambiente') cohort. Maternal doctor-diagnosed anxiety, depression and sleep disorders before and during pregnancy were assessed from the questionnaires completed during pregnancy and 6 months after delivery. Mothers rated child ADHD symptoms at 4 years of age, according to the Diagnostic and Statistical Manual of Mental Disorders. Hyperactive-impulsive (ADHD-H), inattentive (ADHD-I) and total ADHD scores were analysed in the models adjusted for child's gender, first-born status, maternal age, education, alcohol consumption and smoking during pregnancy.

Results.: The total ADHD score at age 4 was associated with maternal lifetime anxiety (17.1% percentage difference in score compared with never; 95% CI 7.3-27.9%), sleep disorders (35.7%; 95% CI 10.7-66.5%) and depression (17.5%; 95% CI 3.2-33.8%). Similar positive associations were observed also for ADHD-H and ADHD-I traits, with slightly attenuated associations between maternal sleep disorders and child ADHD-I score, and maternal depression and both ADHD scores. All the estimates were enhanced when the disorders were active during pregnancy and attenuated for disorders active only during the pre-pregnancy period.

Conclusions.: Maternal anxiety, depression and sleep disorders are associated with a relative increase in the number of ADHD-H, ADHD-I and total ADHD symptoms in preschoolers.

Keywords: Attention-deficit/hyperactivity disorder; mental health; prospective study; risk factors.

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References

    1. Arnett AB, Pennington BF, Willcutt EG, DeFries JC, Olson RK (2015). Sex differences in ADHD symptom severity. Journal of Child Psychology and Psychiatry 56, 632–639. - PMC - PubMed
    1. Association American Psychiatric (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. DSM IV. American Psychiatric Association: Washington, DC.
    1. Association American Psychiatric (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. DSM V. American Psychiatric Association: Washington, DC.
    1. Bazalakova M (2017). Sleep disorders in pregnancy. Seminars in Neurology 37, 661–668. - PubMed
    1. Beijers R, Buitelaar JK, de Weerth C (2014). Mechanisms underlying the effects of prenatal psychosocial stress on child outcomes: beyond the HPA axis. European Child and Adolescent Psychiatry 23, 943–956. - PubMed

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