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Editorial
. 2018 Jun;25(6):1005-1006.
doi: 10.1038/s41418-018-0102-y. Epub 2018 Apr 17.

Oncogene-induced senescence and tumour control in complex biological systems

Lorenzo Galluzzi  1   2   3 , Ilio Vitale  4   5   6
Affiliations
Editorial

Oncogene-induced senescence and tumour control in complex biological systems

Lorenzo Galluzzi et al. Cell Death Differ. 2018 Jun.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Oncogene-induced senescence and tumour control in complex biological systems. Heterogeneous biological systems including cell lines growing in vitro as well as cells constituting animal tissues can respond to potentially tumorigenic stimuli, such as the activation of one oncogene, by undergoing regulated cell death (RCD) or oncogene-induced senescence (OIS). At the cell-intrinsic level, these mechanisms mediate robust oncosuppressive effects as they eliminate neoplastic cell precursors (RCD), or permanently abrogate their proliferative potential (OIS). Moreover, cells undergoing OIS are preferentially recognised and eliminated by the immune system. However, senescent cells that survive such an immune control secrete a variety of biological factors that stimulate the proliferation of neighbouring, non-senescent cells, de facto fostering tumour progression by cell-extrinsic mechanisms. This scenario provides a good example of the heterogeneity of responses in complex biological systems as well as of the co-existence of cell-intrinsic and –extrinsic mechanisms emanating from the same cue but not necessarily culminating in the same outcome
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References

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