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Case Reports
. 2018 Feb 15:2018:4610246.
doi: 10.1155/2018/4610246. eCollection 2018.

Typhoid Fever due to Extended Spectrum β-Lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review

Abdul Azeez Ahamed Riyaaz  1 , Vindya Perera  2 , Sabaratnam Sivakumaran  1 , Nelun de Silva  2
Affiliations
Case Reports

Typhoid Fever due to Extended Spectrum β-Lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review

Abdul Azeez Ahamed Riyaaz et al. Case Rep Infect Dis. .

Abstract

Emergence of cephalosporin-resistant strains of Salmonella enterica serovar Typhi is a cause of concern in the management of enteric fever. Cephalosporin resistance in Salmonella species is mainly due to the production of extended-spectrum β-lactamases (ESBLs). The majority of ESBLs in Salmonella enterica serovar Typhi are derivatives of the TEM, SHV, and CTX-M β-lactamase families. Of these, CTX-M appears to be predominant. This paper discusses the detection and molecular characterization of an ESBL-producing Salmonella enterica serovar Typhi strain isolated from a patient who was admitted to a private hospital in Sri Lanka. The three main types of β-lactamases such as TEM, SHV, and CTX-M were identified in this isolate. This case report from Sri Lanka contributes to the knowledge of the increasingly reported cases of typhoid fever due to Salmonella enterica serovar Typhi resistant to β-lactamase by ESBL production.

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Figures

Figure 1
Figure 1
CLSI confirmatory test for ESBL production with >5 mm increase in zone diameters for combined discs of ceftazidime and cefotaxime with clavulanic acid versus the zone diameter of the agent when tested alone.
Figure 2
Figure 2
Modified double disc synergy test (MDDST) showing synergy between amoxicillin/clavulanate and four cephalosporins.
Figure 3
Figure 3
Gel image of PCR product showing blaTEM gene.
Figure 4
Figure 4
Gel image of the PCR product showing blaSHV gene.
Figure 5
Figure 5
Gel image of the PCR product showing blaCTX-M gene.
See this image and copyright information in PMC

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