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. 1988 May;43(5):571-6.
doi: 10.1038/clpt.1988.75.

The pharmacokinetics of etodolac in serum and synovial fluid of patients with arthritis

M Kraml  1 , D R Hicks, M McKean, J Panagides, D Furst
Affiliations

The pharmacokinetics of etodolac in serum and synovial fluid of patients with arthritis

M Kraml et al. Clin Pharmacol Ther. 1988 May.

Erratum in

  • Clin Pharmacol Ther 1988 Aug;44(2):201. Furst J [corrected to Furst D]

Abstract

The pharmacokinetics of etodolac have been evaluated in five patients with arthritis given 200 mg etodolac, twice daily, at 12-hour intervals, for 7 days. Albumin and total protein concentrations were markedly lower in synovial fluid than in serum, and etodolac free fraction was significantly higher. Etodolac readily penetrated into the synovial fluid, and in the postdistributive phase the concentration of free etodolac (i.e., the drug responsible for pharmacologic activity) remained higher than that in serum at all times. No differences in the half-life of etodolac elimination were noted.

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