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Comment
. 2018 Jul;84(7):1628-1630.
doi: 10.1111/bcp.13588. Epub 2018 Apr 17.

Evident bias in a paracetamol metabolite population pharmacokinetic model applied to an external dataset

Jessica K Roberts  1 , Matthew W Linakis  1   2 , Xiaoxi Liu  1 , Catherine M T Sherwin  1   2   3 , John N van den Anker  4   5   6   7
Affiliations
Comment

Evident bias in a paracetamol metabolite population pharmacokinetic model applied to an external dataset

Jessica K Roberts et al. Br J Clin Pharmacol. 2018 Jul.
No abstract available

Keywords: NONMEM; acetaminophen; external validation; neonate; paracetamol; population pharmacokinetics.

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Figures

Figure 1
Figure 1
(A) Observed plasma and urine concentrations over time versus individual predicted concentrations. (B) Density histogram plot of NPDE with overlaid solid black curves depicting normal distribution for comparison. (C) NPDE plotted against individual predicted concentrations (mg l−1). (D) NPDE plotted against time since previous dose. In all panels, the solid line represents the line of identity and the dotted red line represents the LOESS fits of the data
See this image and copyright information in PMC

Comment on

References

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