Bach2: An Instrument of Heterogeneity for Long-Term Protection

Qiutong Huang¹, Gabrielle T Belz²

Affiliations

¹ Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria, 3052, Australia; Department of Molecular Biology, University of Melbourne, Parkville, Melbourne, Victoria, 3010.
² Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria, 3052, Australia; Department of Molecular Biology, University of Melbourne, Parkville, Melbourne, Victoria, 3010. Electronic address: belz@wehi.edu.au.

PMID: 29669243
DOI: 10.1016/j.immuni.2018.03.033

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Bach2: An Instrument of Heterogeneity for Long-Term Protection

Qiutong Huang et al. Immunity. 2018.

Free article

. 2018 Apr 17;48(4):618-620.

doi: 10.1016/j.immuni.2018.03.033.

Authors

Qiutong Huang¹, Gabrielle T Belz²

Affiliations

¹ Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria, 3052, Australia; Department of Molecular Biology, University of Melbourne, Parkville, Melbourne, Victoria, 3010.
² Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria, 3052, Australia; Department of Molecular Biology, University of Melbourne, Parkville, Melbourne, Victoria, 3010. Electronic address: belz@wehi.edu.au.

PMID: 29669243
DOI: 10.1016/j.immuni.2018.03.033

Abstract

Generation of functionally diverse effector and memory killer T cells is essential for immediate and long-term protective immunity. Herndler-Brandstetter et al. (2018) report that Bach2 promotes functional plasticity of effector T cells and the transition into the long-term memory compartment by regulating the expression of the inhibitory receptor KLRG1.

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KLRG1⁺ Effector CD8⁺ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. Herndler-Brandstetter D, et al. Immunity. 2018 Apr 17;48(4):716-729.e8. doi: 10.1016/j.immuni.2018.03.015. Epub 2018 Apr 3. Immunity. 2018. PMID: 29625895 Free PMC article.

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Bach2: An Instrument of Heterogeneity for Long-Term Protection

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Bach2: An Instrument of Heterogeneity for Long-Term Protection

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Medical