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Comment
. 2018 Apr 17;48(4):628-631.
doi: 10.1016/j.immuni.2018.04.003.

A Hen in the Wolf Den: A Pathobiont Tale

Matteo M Guerrini  1 , Alexis Vogelzang  1 , Sidonia Fagarasan  2
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A Hen in the Wolf Den: A Pathobiont Tale

Matteo M Guerrini et al. Immunity. .
Free article

Abstract

Disruption of the gut microbiota is thought to contribute to disease onset in individuals with a genetic predisposition to autoimmunity. In a recent issue of Science, Manfredo Vieira et al. (2018) identify translocation of the gut commensal Enterococcus gallinarum into the liver as a trigger for the autoimmune disease systemic lupus erythematous.

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  • Translocation of a gut pathobiont drives autoimmunity in mice and humans.
    Manfredo Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta SS, Knight JR, Jain D, Goodman AL, Kriegel MA. Manfredo Vieira S, et al. Science. 2018 Mar 9;359(6380):1156-1161. doi: 10.1126/science.aar7201. Science. 2018. PMID: 29590047 Free PMC article.

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