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Review
. 2018 Apr 18;17(1):57.
doi: 10.1186/s12933-018-0703-2.

Diabetes, cardiovascular disease and the microcirculation

W David Strain  1 , P M Paldánius  2
Affiliations
Review

Diabetes, cardiovascular disease and the microcirculation

W David Strain et al. Cardiovasc Diabetol. .

Erratum in

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors. Hypertension occurs in majority of people with T2DM, which is substantially more frequent than would be anticipated based on general population samples. The impact of hypertension is considerably higher in people with diabetes than it is in the general population, suggesting either an increased sensitivity to its effect or a confounding underlying aetiopathogenic mechanism of hypertension associated with CVD within diabetes. In this contribution, we aim to review the changes observed in the vascular tree in people with T2DM compared to the general population, the effects of established anti-diabetes drugs on microvascular outcomes, and explore the hypotheses to account for common causalities of the increased prevalence of CVD and hypertension in people with T2DM.

Keywords: Cardiovascular disease; Hypertension; Microalbuminuria; Microcirculation; Microvascular changes; Type 2 diabetes mellitus.

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Figures

Fig. 1
Fig. 1
Structural hierarchy of arterial tree in health and disease conditions
See this image and copyright information in PMC

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