Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May;49(5):1091-1098.
doi: 10.1161/STROKEAHA.117.018291. Epub 2018 Apr 18.

Customized Brain Cells for Stroke Patients Using Pluripotent Stem Cells

Zaal Kokaia  1 , Irene L Llorente  2 , S Thomas Carmichael  3
Affiliations
Review

Customized Brain Cells for Stroke Patients Using Pluripotent Stem Cells

Zaal Kokaia et al. Stroke. 2018 May.
No abstract available

Keywords: brain; inflammation; neurogenesis; regeneration; stem cell.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Application of pluripotent stem cells in cell therapy for stroke-injured brain
(i) Pluripotent stem cells can be derived from blastocyst (embryonic stem cells, ESCs) or through reprogramming of post-mitotic somatic cells, most commonly fibroblasts, generating induced pluripotent stem cells (iPSCs). (ii) Both ESCs and iPSCs can be treated in vitro to generate glia and neurons. (iii) Transplantation of glial and neuronal cells at early stages of their development into stroke-injured brain can lead to functional recovery through promotion of myelinogenesis and/or restoration of astrocyte network (glia) or by increasing cellular plasticity and/or restoring neuronal network (neurons).
See this image and copyright information in PMC

References

    1. Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol. 2001;19:1129–1133. - PubMed
    1. Erceg S, Lainez S, Ronaghi M, Stojkovic P, Perez-Arago MA, Moreno-Manzano V, et al. Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS One. 2008;3:e2122. - PMC - PubMed
    1. Falk A, Koch P, Kesavan J, Takashima Y, Ladewig J, Alexander M, et al. Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One. 2012;7:e29597. - PMC - PubMed
    1. Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, et al. Efficient derivation of npcs, spinal motor neurons and midbrain dopaminergic neurons from hescs at 3% oxygen. Nat Protoc. 2011;6:1229–1240. - PMC - PubMed
    1. Erceg S, Ronaghi M, Zipancic I, Lainez S, Rosello MG, Xiong C, et al. Efficient differentiation of human embryonic stem cells into functional cerebellar-like cells. Stem Cells Dev. 2010;19:1745–1756. - PubMed

Publication types

MeSH terms