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Review
. 2018 May;49(5):1083-1090.
doi: 10.1161/STROKEAHA.117.018292. Epub 2018 Apr 18.

Exosome Therapy for Stroke

Jieli Chen  1   2   3 , Michael Chopp  1   4
Affiliations
Review

Exosome Therapy for Stroke

Jieli Chen et al. Stroke. 2018 May.
No abstract available

Keywords: exosomes; lipids; mesenchymal stromal cells; microRNAs; stroke.

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Figures

Figure 1
Figure 1. Summary the therapeutic effects of exosome in stroke
1) Intravenous administration of exosomes can pass the BBB and are taken up by endogenous brain cells. 2) Exosomes contain miRs, mRNA and proteins (such as CD81, CD63, CD9, Alix et al, as well as cell type specific antigens); 3) Exosomes interact with target cells and transfer their RNA, miR and protein content by: A: the endocytosis route (pinocytosis and phagocytosis); B: direct fusion with the plasma membrane; C: binding to target cell via ligand-receptor interactions (such as integrins, tetraspanins and intercellular adhesion molecules). 4) Exosomes communicate with endogenous brain cells and induce neurogenesis, white matter/axonal and vascular remodeling, as well as inhibit neuroinflammation, and thereby promote neuroprotective or neurorestorative effects, as well as improve functional outcome after stroke.
See this image and copyright information in PMC

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