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Review
. 2018 May;49(5):1075-1082.
doi: 10.1161/STROKEAHA.117.018288. Epub 2018 Apr 18.

Intra-Arterial Delivery of Cell Therapies for Stroke

Raphael Guzman  1 , Miroslaw Janowski  2   3   4   5 , Piotr Walczak  6   3   7
Affiliations
Review

Intra-Arterial Delivery of Cell Therapies for Stroke

Raphael Guzman et al. Stroke. 2018 May.
No abstract available

Keywords: brain; cell size; liver; neuroprotection; spleen.

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Conflict of interest statement

Disclosures

Authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Safety and success of IA cell delivery has been shown to depend in part on cell type and size, cell dose, infusion speed and timing of cell transplantation after stroke onset.
Figure 2
Figure 2
Clinical Perspective on therapeutic intra-arterial cell delivery after stroke. Imaging of cell delivery should become an integral part of cell transplantation studies. Modern imaging has the potential to demonstrate the anatomical biodistribution of cells after injection. Recent advances in MR imaging enables real-time monitoring of cellular delivery and anatomical distribution. Hybrid OR suite may offer the necessary infrastructure for state of the art IA cell transplantation.
Figure 3
Figure 3
Improving the efficiency of cell delivery. Different strategies to improve transendothelial cell homing to the brain have been developed including fluorescence activated cell sorting (FACS) to select cells with high expression of surface adhesion molecules and genetic cell modification of enhance adhesion molecule and chemokine receptor expression.
Figure 4
Figure 4
The role of IA stem cell-based therapy in the context of standard treatment algorithm
See this image and copyright information in PMC

References

    1. Savitz SI, Cramer SC, Wechsler L, Consortium S Stem cells as an emerging paradigm in stroke 3: Enhancing the development of clinical trials. Stroke. 2014;45:634–639. - PMC - PubMed
    1. Misra V, Ritchie MM, Stone LL, Low WC, Janardhan V. Stem cell therapy in ischemic stroke: Role of iv and intra-arterial therapy. Neurology. 2012;79:S207–212. - PMC - PubMed
    1. Pendharkar AV, Chua JY, Andres RH, Wang N, Gaeta X, Wang H, et al. Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia. Stroke. 2010;41:2064–2070. - PMC - PubMed
    1. Auriat AM, Rosenblum S, Smith TN, Guzman R. Intravascular stem cell transplantation for stroke. Transl Stroke Res. 2011;2:250–265. - PubMed
    1. Fukuda Y, Horie N, Satoh K, Yamaguchi S, Morofuji Y, Hiu T, et al. Intra-arterial transplantation of low-dose stem cells provides functional recovery without adverse effects after stroke. Cell Mol Neurobiol. 2015;35:399–406. - PMC - PubMed

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