Are most cancer cases a consequence of an immune deficiency caused by thymic involution?
- PMID: 29669914
- PMCID: PMC5949010
- DOI: 10.1073/pnas.1803180115
Are most cancer cases a consequence of an immune deficiency caused by thymic involution?
Conflict of interest statement
The authors declare no conflict of interest.
Comment in
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Reply to Jiménez-Alonso et al., Schooling and Zhao, and Mortazavi: Further discussion on the immunological model of carcinogenesis.Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4319-E4321. doi: 10.1073/pnas.1802809115. Epub 2018 Apr 18. Proc Natl Acad Sci U S A. 2018. PMID: 29669926 Free PMC article. No abstract available.
Comment on
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Thymic involution and rising disease incidence with age.Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1883-1888. doi: 10.1073/pnas.1714478115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432166 Free PMC article.
References
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- López-Lázaro M. The stem cell division theory of cancer. Crit Rev Oncol Hematol. 2018;123:95–113. - PubMed
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- Stutman O. Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice. Science. 1974;183:534–536. - PubMed
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- Sharkey FE, Fogh J. Incidence and pathological features of spontaneous tumors in athymic nude mice. Cancer Res. 1979;39:833–839. - PubMed
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