Reply to Jiménez-Alonso et al., Schooling and Zhao, and Mortazavi: Further discussion on the immunological model of carcinogenesis

Sam Palmer^{1

2}, Luca Albergante^{3

4}, Clare C Blackburn⁵, T J Newman^{1

6}

Affiliations

¹ School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom; s.palmer@hw.ac.uk tjnewman@solaravus.com.
² School of Mathematical & Computer Sciences, Heriot-Watt University Malaysia, 62200 Putrajaya, Malaysia.
³ School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom.
⁴ Institut Curie, Université de Recherche Paris Sciences et Lettres, Mines ParisTech, INSERM U900, F-75005 Paris, France.
⁵ Medical Research Council Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.
⁶ Solaravus, Cupar KY15 9AS, United Kingdom.

Comment

Sam Palmer et al. Proc Natl Acad Sci U S A. 2018.

. 2018 May 8;115(19):E4319-E4321.

doi: 10.1073/pnas.1802809115. Epub 2018 Apr 18.

Sam Palmer^{1

2}, Luca Albergante^{3

4}, Clare C Blackburn⁵, T J Newman^{1

6}

¹ School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom; s.palmer@hw.ac.uk tjnewman@solaravus.com.
² School of Mathematical & Computer Sciences, Heriot-Watt University Malaysia, 62200 Putrajaya, Malaysia.
³ School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom.
⁴ Institut Curie, Université de Recherche Paris Sciences et Lettres, Mines ParisTech, INSERM U900, F-75005 Paris, France.
⁵ Medical Research Council Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.
⁶ Solaravus, Cupar KY15 9AS, United Kingdom.

No abstract available

Conflict of interest statement

The authors declare no conflict of interest.

Thymic involution and rising disease incidence with age.
Palmer S, Albergante L, Blackburn CC, Newman TJ. Palmer S, et al. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1883-1888. doi: 10.1073/pnas.1714478115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432166 Free PMC article.
Are most cancer cases a consequence of an immune deficiency caused by thymic involution?
Jiménez-Alonso JJ, Calderón-Montaño JM, López-Lázaro M. Jiménez-Alonso JJ, et al. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4314-E4315. doi: 10.1073/pnas.1803180115. Epub 2018 Apr 18. Proc Natl Acad Sci U S A. 2018. PMID: 29669914 Free PMC article. No abstract available.
Strengthening the immune system for cancer prevention.
Schooling CM, Zhao JV. Schooling CM, et al. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4316-E4317. doi: 10.1073/pnas.1802584115. Epub 2018 Apr 18. Proc Natl Acad Sci U S A. 2018. PMID: 29669915 Free PMC article. No abstract available.
Shortcomings of the immunological model of carcinogenesis.
Mortazavi SMJ. Mortazavi SMJ. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4318. doi: 10.1073/pnas.1802507115. Epub 2018 Apr 18. Proc Natl Acad Sci U S A. 2018. PMID: 29669916 Free PMC article. No abstract available.

1. Palmer S, Albergante L, Blackburn CC, Newman TJ. Thymic involution and rising disease incidence with age. Proc Natl Acad Sci USA. 2018;115:1883–1888. - PMC - PubMed
1. Jiménez-Alonso JJ, Calderón-Montaño JM, López-Lázaro M. Are most cancer cases a consequence of an immune deficiency caused by thymic involution? Proc Natl Acad Sci USA. 2018;115:E4314–E4315. - PMC - PubMed
1. Schooling CM, Zhao JV. Strengthening the immune system for cancer prevention. Proc Natl Acad Sci USA. 2018;115:E4316–E4317. - PMC - PubMed
1. Mortazavi SMJ. Shortcomings of the immunological model of carcinogenesis. Proc Natl Acad Sci USA. 2018;115:E4318. - PMC - PubMed
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