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. 2018 Apr 18;8(1):6180.
doi: 10.1038/s41598-018-24279-1.

Clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome

Huaxia Yang  1   2 , Sainan Bian  1   2 , Hua Chen  1   2 , Li Wang  1   2 , Lidan Zhao  1   2 , Xuan Zhang  1   2 , Yan Zhao  1   2 , Xiaofeng Zeng  1   2 , Fengchun Zhang  3   4
Affiliations

Clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome

Huaxia Yang et al. Sci Rep. .

Abstract

This study investigated the clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome (RA/SS). Patients with RA/SS in Peking Union Medical College Hospital from January 2012 to January 2017 were retrospectively analysed and compared to those of sex- and age-matched RA or SS controls. Logistic regression analysis was used to identify risk factors. Altogether, 105 consecutive patients with RA/SS were enrolled. Ninety-seven (92.4%) of them were female, with a mean age of 51.5 ± 13.3 years or 45.2 ± 14.7years at the diagnosis of SS or RA, respectively. In addition to arthritis and Sicca symptom, patients with RA/SS had more visceral involvements including interstitial lung disease (ILD), and haematologic involvement, and received more glucocorticoid treatments than controls (p < 0.05). RA-onset, simultaneous-onset and SS-onset patients had significant differences in age at RA diagnosis, fever and thrombocytopenia (p < 0.05). Multivariate logistic analysis indicated that arthritis (OR = 44.804), rheumatoid factor (RF) (OR = 5.973), and anti-CCP (OR = 2.545) were independent risk factors for SS overlapping with RA. Xerostomia (OR = 3.960), ILD (OR = 6.210), and anti-SSA (OR = 24.640) were independent predictors of RA overlapping with SS. RA/SS patients have more visceral involvements. Our findings highlight the roles of arthritis/RF/anti-CCP and xerostomia/ILD/anti-SSA in the development of this overlapping disease.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The candidate clinical and biologic parameters for the overlap diseases. (A) Comparisons of clinical parameters among patients with RA/SS and controls. (B) Comparisons of biologic parameters among patients with RA/SS and controls. RA: Rheumatoid arthritis; SS: Sjogren syndrome; ILD: Interstitial lung disease; ANA: Anti-nuclear antibody; Anti-Ro/SSA: Anti-Ro/SSA antibody; Anti-La/SSB: Anti-La/SSB antibody; RF: Rheumatoid factor; Anti-CCP: Anti-cyclic peptide containing citrullin antibody.
See this image and copyright information in PMC

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