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. 2018 Mar;8(1):141-147.
doi: 10.15171/apb.2018.017. Epub 2018 Mar 18.

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Basiru Olaitan Ajiboye  1 , Oluwafemi Adeleke Ojo  1 , Oluwatosin Adeyonu  1 , Oluwatosin Imiere  1 , Babatunji Emmanuel Oyinloye  1 , Oluwafemi Ogunmodede  2
Affiliations

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Basiru Olaitan Ajiboye et al. Adv Pharm Bull. 2018 Mar.

Abstract

Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days. Results: At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats. Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.

Keywords: Alloxan; Artocarpus heterophyllus stem bark; Haematological parameters; Serum lipid profiles.

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References

    1. Sada NM, Tanko Y, Mabrouk MA. Modulatory role of soya beans supplement on lipid profiles and liver enzymes on alloxan-induced diabetic Wistar rats. Eur J Exp Bio. 2013;3(2):62–7.
    1. Hesham ZT, Hassan NM, Khalil HI, Kerolles SY. Antidiabetic effects of dietary formulas prepared from some grains and vegetables on type 2 diabetic rats. J Agroaliment Proc Technol. 2014;20(1):69–79.
    1. Azeez OI, Oyagbemi AA, Oyeyemi MO, Odetola AA. Ameliorative effects of cnidoscolus aconitifolius on alloxan toxicity in wistar rats. Afr Health Sci. 2010;10(3):283–91. - PMC - PubMed
    1. Anaelechi JO, Japhet MO, Ude T, Ubuo KA, John EO, Ifeadike C. et al. Effects of Telfairia occidentalis seeds on the serum lipid profile and atherogenic indices of male albino Wistar rats. Pak J Nutr. 2015;14(9):557–62. doi: 10.3923/pjn.2015.557.562. - DOI
    1. Hung HY, Qian K, Morris-Natschke SL, Hsu CS, Lee KH. Recent discovery of plant-derived anti-diabetic natural products. Nat Prod Rep. 2012;29(5):580–606. doi: 10.1039/c2np00074a. - DOI - PubMed

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