[Advances in the Pathogenesis of Abdominal Aortic Aneurysms and Inflammation]

Abstract

Abdominal aortic aneurysm (AAA)is one of the most catastrophic arterial disease,with the severe outcome of sudden death due to the aortic rupture of weak arterial wall.Currently there is a lack of effective drug therapy for AAAs.Since the aging population situation is worsening,the prevalence of AAAs is rising constantly in China.There has already been plenty of factors known,which could led to AAA,however,the mechanism of AAA has not been very clearly.It has been recognized that many risk factors contribute to the development of AAA such as smoking,reactive oxygen species,matrix metallo-proteinase,and atherosclerosis,however,the mechanism of AAA formation has not been well under-stood.With the recent progressions in researches on inflammation and AAA,the role of inflammation in the pathogenesis of AAA has drawn increasing attention..This review will summarize recent advances in the investigations of leukocyte related mechanisms of aneurismal initiation and progression.