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Comparative Study
. 2018 Jun 1;22(2):139-147.
doi: 10.5935/1518-0557.20180027.

Physiological ICSI (PICSI) vs. Conventional ICSI in Couples with Male Factor: A Systematic Review

Georgina Avalos-Durán  1 , Ana María Emilia Cañedo-Del Ángel  2 , Juana Rivero-Murillo  3 , Jaime Enoc Zambrano-Guerrero  4 , Esperanza Carballo-Mondragón  5 , Miguel Ángel Checa-Vizcaíno  6
Affiliations
Comparative Study

Physiological ICSI (PICSI) vs. Conventional ICSI in Couples with Male Factor: A Systematic Review

Georgina Avalos-Durán et al. JBRA Assist Reprod. .

Abstract

Objectives: To determine the efficacy of the physiological ICSI technique (PICSI) vs. conventional ICSI in the prognosis of couples, with respect to the following outcome measures: live births, clinical pregnancy, implantation, embryo quality, fertilization and miscarriage rates.

Methods: A systematic review of the literature, extracting raw data and performing data analysis. Patient(s): Couples with the male factor, who were subjected to in-vitro fertilization. Main Outcome Measures: rates of live births, clinical pregnancy, implantation, embryo quality, fertilization and miscarriage.

Results: In the systematic search, we found 2,918 studies and an additional study from other sources; only two studies fulfilled the inclusion criteria for this systematic review. The rates of live births, clinical pregnancy, implantation, embryo quality, fertilization and miscarriage were similar for both groups.

Conclusion: There is no statistically significant difference between PICSI vs. ICSI, for any of the outcomes analyzed in this study. Enough information is still not available to prove the efficacy of the PICSI technique over ICSI in couples with male factor.

Keywords: HA sperm selection; PICSI; hyaluronic acid; male factor; physiological ICSI.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Flow diagram illustrating the selection of trials included in the meta-analysis
Figure 2
Figure 2
Risks of bias of the included studies
Figure 3
Figure 3
Effects of interventions
See this image and copyright information in PMC

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