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. 2018 Apr 19;18(1):60.
doi: 10.1186/s12890-018-0623-7.

Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?

Daniela Savi  1   2 , Marcello Di Paolo  3 , Nicholas J Simmonds  4 , Chiara Pascucci  5 , Serena Quattrucci  6 , Paolo Palange  3   7
Affiliations

Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?

Daniela Savi et al. BMC Pulm Med. .

Abstract

Background: The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF).

Methods: Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related measurements included: oxygen uptake (V'O2), carbon dioxide production (V'CO2), ventilatory profile, work rate (W), inspiratory capacity (IC), end-expiratory lung volume (EELV). PA was assessed using the accelerometer SenseWear Pro3 Armband.

Results: Exercise tolerance was reduced in most of patients and the mean V'O2,peak value was 75.2% of predicted (28.5 ± 4.8 ml/min/kg). Seventy % of patients responded to CPET with dynamic hyperinflation. Higher incidence of dynamic hyperinflation was found in CF males compared to CF females (p = 0.026). Patients who developed dynamic hyperinflation during CPET had higher vigorous PA (p = 0.01) and more total energy expenditure (p = 0.006) than patients who did not. EELVΔ was related to activities requiring vigorous intensity and total energy expenditure (R = 0.46, p = 0.001; R = 0.57, p < 0.001).

Conclusions: In adults with CF and mild to moderate lung impairment, DPA might not be limited by dynamic hyperinflation.

Keywords: Cystic fibrosis; Daily physical activity; Dynamic hyperinflation; Exercise intolerance.

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Conflict of interest statement

Ethics approval and consent to participate

Approval for this study was obtained from the Ethics Committee of the Policlinico Umberto I Hospital. All patients were asked to sign an informed consent form authorizing inclusion of their clinical data in the study database.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Relationship between total energy expenditure in daily living recorded by accelerometer and change in end-expiratory lung volume (EELV) in patients with cystic fibrosis (R = 0.57, p < 0.001). In this figure, the most hyperinflated CF patients, those with the highest EELV, also showed the highest physical activity parameter represented as total energy expenditure. Open circles = CF patients with dynamic hyperinflation, closed circles = CF patients without dynamic hyperinflation
See this image and copyright information in PMC

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