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. 2018 Apr 20;360(6386):270-271.
doi: 10.1126/science.aat3470.

A unifying concept in vascular health and disease

Affiliations

A unifying concept in vascular health and disease

Martin A Schwartz et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. Persistent instability and disease.
Local signals activate blood vessel endothelial cells (ECs), triggering events that transform ECs and create further instability. This is a feedforward cycle, as instability leads to matrix remodeling, leukocyte recruitment, inflammation, and EC transformation, which accelerates matrix remodeling and so on. Long duration of this process may lead to numerous pathologies. ROS, reactive oxygen species.

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