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Comment
. 2018 Oct;102(10):1593-1594.
doi: 10.1097/TP.0000000000002238.

Dendritic Cell Therapy in Transplantation, Phenotype Governs Destination and Function

Kannan P Samy  1 , Todd V Brennan  2
Affiliations
Comment

Dendritic Cell Therapy in Transplantation, Phenotype Governs Destination and Function

Kannan P Samy et al. Transplantation. 2018 Oct.
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Dendritic cell phenotype governs localization and function
Inflammatory signals in peripheral tissues cause DC activation and maturation into mDCs. Based on the upregulation of specific chemokine receptors and adhesion molecules, mDCs traffic to lymph nodes and promote immune stimulation. Circulating from healthy peripheral tissues, imDCs can bypass lymph nodes and migrate to the thymus and promote immune tolerance to peripheral antigen. Illustrated by Megan Llewellyn, MSMI; copyright Duke University; with permission under a CC BY-ND 4.0 license
See this image and copyright information in PMC

Comment on

References

    1. Scalea JR, Tomita Y, Lindholm CR, Burlingham W. Transplantation Tolerance Induction: Cell Therapies and Their Mechanisms. Front Immunol. 2016;7(1):87. - PMC - PubMed
    1. Ezzelarab M, Thomson AW. Tolerogenic dendritic cells and their role in transplantation. Semin Immunol. 2011;23(4):252–263. - PMC - PubMed
    1. Rosen SJ, Harris PE, Hardy MA. State of the Art: Role of the Dendritic Cell in Induction of Allograft Tolerance. Transplantation. 2018 In Press. - PMC - PubMed
    1. Brennan TV, Jaigirdar A, Hoang V, et al. Preferential priming of alloreactive T cells with indirect reactivity. Am J Transplant. 2009;9(4):709–718. - PMC - PubMed
    1. Carretero-Iglesia L, Bouchet-Delbos L, Louvet C, et al. Comparative Study of the Immunoregulatory Capacity of In Vitro Generated Tolerogenic Dendritic Cells, Suppressor Macrophages, and Myeloid-Derived Suppressor Cells. Transplantation. 2016;100(10):2079–2089. - PubMed