Chilled in Translation: Adapting to Bacterial Climate Change
- PMID: 29677488
- DOI: 10.1016/j.molcel.2018.04.003
Chilled in Translation: Adapting to Bacterial Climate Change
Abstract
Cold-shocked bacteria transiently shut down protein translation, but the mechanisms whereby they adaptively restore translation were incompletely understood. Zhang et al. (2018) demonstrate a global increase in mRNA structure after cold shock and that, as structured RNA decreases, translation returns, dependent upon ribonuclease RNase R and cold shock protein CspA and its homologs.
Published by Elsevier Inc.
Comment on
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A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.Mol Cell. 2018 Apr 19;70(2):274-286.e7. doi: 10.1016/j.molcel.2018.02.035. Epub 2018 Apr 5. Mol Cell. 2018. PMID: 29628307 Free PMC article.
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