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Comment
. 2018 Apr 19;173(3):542-544.
doi: 10.1016/j.cell.2018.04.001.

A Mechanosensitive GPCR that Detects the Bloody Force

Adam J Iliff  1 , X Z Shawn Xu  2
Affiliations
Comment

A Mechanosensitive GPCR that Detects the Bloody Force

Adam J Iliff et al. Cell. .

Abstract

Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.

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Figures

Fig. 1
Fig. 1
(A) Shear stress arising from fluid flow across a surface parallel to the direction of flow. (B) GPR68 detects flow-mediated shear stress, which activates Gαq/11 signaling and increases intracellular Ca2+ levels.
See this image and copyright information in PMC

Comment on

  • GPR68 Senses Flow and Is Essential for Vascular Physiology.
    Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A. Xu J, et al. Cell. 2018 Apr 19;173(3):762-775.e16. doi: 10.1016/j.cell.2018.03.076. Cell. 2018. PMID: 29677517 Free PMC article.

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