Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma
- PMID: 29677645
- PMCID: PMC6108938
- DOI: 10.1016/j.coph.2018.04.003
Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma
Abstract
Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Conflict of interest statement
None.
Figures


Similar articles
-
Identification and validation of an autophagy-related gene signature for predicting prognosis in patients with esophageal squamous cell carcinoma.Sci Rep. 2022 Feb 4;12(1):1960. doi: 10.1038/s41598-022-05922-4. Sci Rep. 2022. PMID: 35121801 Free PMC article.
-
Roles for Autophagy in Esophageal Carcinogenesis: Implications for Improving Patient Outcomes.Cancers (Basel). 2019 Oct 31;11(11):1697. doi: 10.3390/cancers11111697. Cancers (Basel). 2019. PMID: 31683722 Free PMC article. Review.
-
Development of chemotherapeutics for unresectable advanced esophageal cancer.Expert Rev Anticancer Ther. 2020 Dec;20(12):1083-1092. doi: 10.1080/14737140.2020.1814149. Epub 2020 Nov 25. Expert Rev Anticancer Ther. 2020. PMID: 32820965 Review.
-
Clinical and translational advances in esophageal squamous cell carcinoma.Adv Cancer Res. 2019;144:95-135. doi: 10.1016/bs.acr.2019.05.004. Epub 2019 Jun 10. Adv Cancer Res. 2019. PMID: 31349905 Review.
-
Impact of APOBEC3s on the occurrence, development and prognosis of esophageal squamous cell carcinoma.Future Oncol. 2025 Jan;21(1):117-125. doi: 10.1080/14796694.2024.2442300. Epub 2024 Dec 30. Future Oncol. 2025. PMID: 39840662 Free PMC article. Review.
Cited by
-
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics.Crit Rev Oncog. 2018;23(5-6):281-305. doi: 10.1615/CritRevOncog.2018027211. Crit Rev Oncog. 2018. PMID: 30311561 Free PMC article. Review.
-
Silencing of integrin subunit α3 inhibits the proliferation, invasion, migration and autophagy of esophageal squamous cell carcinoma cells.Oncol Lett. 2022 Jun 20;24(2):271. doi: 10.3892/ol.2022.13391. eCollection 2022 Aug. Oncol Lett. 2022. PMID: 35782901 Free PMC article.
-
PRR11 in Malignancies: Biological Activities and Targeted Therapies.Biomolecules. 2022 Dec 1;12(12):1800. doi: 10.3390/biom12121800. Biomolecules. 2022. PMID: 36551227 Free PMC article. Review.
-
Beclin-1 is a Promising Prognostic Biomarker in a Specific Esophageal Squamous Cell Carcinoma Population.Pathol Oncol Res. 2021 Apr 9;27:594724. doi: 10.3389/pore.2021.594724. eCollection 2021. Pathol Oncol Res. 2021. PMID: 34257544 Free PMC article.
-
Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma.Theranostics. 2020 Apr 6;10(11):4983-4996. doi: 10.7150/thno.43046. eCollection 2020. Theranostics. 2020. PMID: 32308763 Free PMC article.
References
-
- Rustgi AK, El-Serag HB. Esophageal carcinoma. N Engl J Med. 2014;371:2499–2509. - PubMed
-
- Hanawa M, Suzuki S, Dobashi Y, Yamane T, Kono K, Enomoto N, Ooi A. EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus. Int J Cancer. 2006;118:1173–1180. - PubMed
-
- Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, et al. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014;509:91–95. - PubMed
-
- Network CGAR, University AWGA, Agency BC, et al. Hospital BaWs, Institute B, University B, University CWR, Institute D-FC, University D, Centre GPC. Integrated genomic characterization of oesophageal carcinoma. Nature. 2017;541:169–175. The authors perform comprehensive molecular analysis of 164 esophageal tumors, identifying three distinct molecular subtypes of ESCC, two of which featured deep deletions in ATG7 in up to 25% of cases. - PMC - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical