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Comment
. 2018 Jul;15(7):394-395.
doi: 10.1038/s41575-018-0012-y.

Gut development on a full stomach

Arthur Beyder  1
Affiliations
Comment

Gut development on a full stomach

Arthur Beyder. Nat Rev Gastroenterol Hepatol. 2018 Jul.

Abstract

Mechanical forces are important for normal gastrointestinal development and function. Now, He et al. have discovered a population of Drosophila midgut epithelial enteroendocrine cell (EEC) precursors that express the mechanosensitive ion channel Piezo, which generates a calcium influx that drives EEC differentiation and proliferation in response to physiological mechanical stimuli.

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Conflict of interest statement

Competing interests

The author declares no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Mechanical forces trigger enteroendocrine cell differentiation in Drosophila midgut.
Piezo+ enteroendocrine cell (EEC) precursors give rise to Piezo+ EECs when stimulated by mechanical forces.
See this image and copyright information in PMC

Comment on

References

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