Randomized Controlled Trial

. 2018 Jul 1:191:138-145.

doi: 10.1016/j.physbeh.2018.04.026. Epub 2018 Apr 19.

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Gary S Goldfield¹, Glen P Kenny², Denis Prud'homme³, Martin Holcik⁴, Angela S Alberga⁵, Margaret Fahnestock⁶, Jameason D Cameron⁷, Steve Doucette⁸, Stasia Hadjiyannakis⁹, Heather Tulloch¹⁰, Mark S Tremblay¹¹, Jeremy Walsh⁷, Eva Guerin³, Katie E Gunnell¹², Amedeo D'Angiulli¹³, Ronald J Sigal¹⁴

Affiliations

¹ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada; School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; School of Psychology, University of Ottawa, Ottawa, ON, Canada. Electronic address: ggoldfield@cheo.on.ca.
² School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
³ Institut du Savoir Montfort, Ottawa, ON, Canada.
⁴ Department of Health Sciences, Carleton University, Ottawa, ON, Canada.
⁵ Department of Kinesiology, Concordia University, Montreal, QC, Canada.
⁶ Department of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
⁷ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
⁸ Department of Community Health & Epidemiology, Dalhousie University, Halifax, NS, Canada.
⁹ Centre for Healthy Active Living, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
¹⁰ Prevention & Rehabilitation Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada.
¹¹ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
¹² Department of Psychology, Carleton University, Ottawa, ON, Canada.
¹³ Department of Neuroscience, Carleton University, Ottawa, ON, Canada.
¹⁴ School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Departments of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

PMID: 29679660
DOI: 10.1016/j.physbeh.2018.04.026

Randomized Controlled Trial

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Gary S Goldfield et al. Physiol Behav. 2018.

. 2018 Jul 1:191:138-145.

doi: 10.1016/j.physbeh.2018.04.026. Epub 2018 Apr 19.

Authors

Affiliations

¹ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada; School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; School of Psychology, University of Ottawa, Ottawa, ON, Canada. Electronic address: ggoldfield@cheo.on.ca.
² School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
³ Institut du Savoir Montfort, Ottawa, ON, Canada.
⁴ Department of Health Sciences, Carleton University, Ottawa, ON, Canada.
⁵ Department of Kinesiology, Concordia University, Montreal, QC, Canada.
⁶ Department of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
⁷ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
⁸ Department of Community Health & Epidemiology, Dalhousie University, Halifax, NS, Canada.
⁹ Centre for Healthy Active Living, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
¹⁰ Prevention & Rehabilitation Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada.
¹¹ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
¹² Department of Psychology, Carleton University, Ottawa, ON, Canada.
¹³ Department of Neuroscience, Carleton University, Ottawa, ON, Canada.
¹⁴ School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Departments of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

PMID: 29679660
DOI: 10.1016/j.physbeh.2018.04.026

Erratum in

Corrigendum to "Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial" Physiology & Behavior, Volume 191, 1 July 2018, Pages 138-145.
Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay MS, Walsh J, Guerin E, Gunnell KE, D'Angiulli A, Sigal RJ. Goldfield GS, et al. Physiol Behav. 2019 Jan 1;198:161. doi: 10.1016/j.physbeh.2018.06.019. Epub 2018 Jun 30. Physiol Behav. 2019. PMID: 30428994 No abstract available.

Abstract

Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14-18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76). All participants received dietary counseling targeting a daily energy deficit of 250 kcal. The exercise prescription was 4 times per week, progressing to 45 min/session for the aerobic and resistance groups and 90 min/session for the combined group. Resting serum BDNF levels were measured at baseline and 6-months. Results showed that in both intention-to-treat (ITT) and per protocol (≥70% adherence to prescribed sessions) analyses, there were no significant within- or between-group changes in BDNF. Findings indicate that aerobic training, resistance training or their combination did change serum BDNF levels in adolescents with overweight and obesity.

Trial registration: ClinicalTrials.Gov NCT00195858 http://clinicaltrials.gov/show/NCT00195858, September 12, 2005 (Funded by the Canadian Institutes of Health Research).

Keywords: Adolescents; BDNF; Cognition; Exercise; Obesity; Physical activity; Strength training.

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Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Affiliations

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Authors

Affiliations

Erratum in

Abstract

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MeSH terms

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Associated data

Grants and funding

LinkOut - more resources

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Medical