Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 May;93(5):1038-1040.
doi: 10.1016/j.kint.2018.01.012.

Unraveling the mechanisms of obesity-induced hyperoxaluria

Khashayar Sakhaee  1
Affiliations
Comment

Unraveling the mechanisms of obesity-induced hyperoxaluria

Khashayar Sakhaee. Kidney Int. 2018 May.

Abstract

Kidney stones is increasingly associated with obesity. With an increasing prevalence of obesity and metabolic syndrome in the past 30 years, urinary oxalate has significantly increased. However, its underlying pathophysiologic mechanisms of hyperoxaluria have not been fully explored. This preclinical study suggests that hyperoxaluria in obesity depends on a complex network of inflammatory responses linked to metabolic outcome. The future mechanistic and clinical investigations must be targeted at elucidating the pathogenetic role of inflammation in obesity induced hyperoxaluria.

PubMed Disclaimer

Conflict of interest statement

DISCLOSURE

The author declared no competing interests.

Figures

Figure 1
Figure 1. Potential pathophysiologic mechanisms of obesity-induced hyperoxaluria
(i) Increased dietary ingestion of oxalate; (ii) increased net intestinal absorption of oxalate; (iii) alteration in intestinal microbiota leading to decreased intestinal bacterial metabolism of oxalate; (iv) excessive endogenous oxalate production in the liver; (v) increased circulating and intestinal proinflammatory cytokines; (vi) hyperoxaluria. IFN, interferon; IL-6, interleukin-6; TNF, tumor necrosis factor.
See this image and copyright information in PMC

Comment on

References

    1. Sakhaee K. Nephrolithiasis as a systemic disorder. Curr Opin Nephrol Hypertens. 2008;17:304–309. - PubMed
    1. Pak CY, Adams-Huet B, Poindexter JR, Pearle MS, Peterson RD, Moe OW. Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalate. Kidney Int. 2004;66:2032–2037. - PubMed
    1. Xu LHR, Adams-Huet B, Poindexter JR, Maalouf NM, Moe OW, Sakhaee K. Temporal changes in kidney stone composition and in risk factors predisposing to stone formation. J Urol. 2017;197:1465–1471. - PMC - PubMed
    1. Amin R, Asplin J, Jung D, et al. Reduced active transcellular intestinal oxalate secretion contributes to the pathogenesis of obesity-associated hyperoxaluria. Kidney Int. 2018;93:1098–1107. - PMC - PubMed
    1. Wang Z, Petrovic S, Mann E, Soleimani M. Identification of an apical Cl(−)/HCO3(−) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2002;282:G573–G579. - PubMed

Publication types

LinkOut - more resources