Review
doi: 10.1016/bs.apcsb.2018.03.004.
Epub 2018 Apr 6.
Linear Analogues of the Lipopeptide Battacin With Potent In Vitro Activity Against S. aureus
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- PMID: 29680242
- DOI: 10.1016/bs.apcsb.2018.03.004
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Review
Linear Analogues of the Lipopeptide Battacin With Potent In Vitro Activity Against S. aureus
Adv Protein Chem Struct Biol.
2018.
Abstract
Eight linear analogues of the lipopeptide battacin were evaluated for their antibacterial activity against the Gram-positive Staphylococcus aureus. Of this library, the enantiomeric lipopeptide analogue 9.4 exhibited nanomolar inhibitory activity (MIC=200nmol) against S. aureus. Furthermore, this lipopeptide was resilient toward degradation conditions when exposed to rat serum proteases for up to 8h.
Keywords: Lipopeptide; Resistance; S. aureus; Serum stability.
© 2018 Elsevier Inc. All rights reserved.
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