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. 2018 Jul:117:50-56.
doi: 10.1016/j.urology.2018.04.008. Epub 2018 Apr 20.

The Receipt of Industry Payments is Associated With Prescribing Promoted Alpha-blockers and Overactive Bladder Medications

Parth K Modi  1 , Ye Wang  2 , Peter S Kirk  3 , James M Dupree  3 , Eric A Singer  4 , Steven L Chang  2
Affiliations

The Receipt of Industry Payments is Associated With Prescribing Promoted Alpha-blockers and Overactive Bladder Medications

Parth K Modi et al. Urology. 2018 Jul.

Abstract

Objective: To determine the impact of physicians' financial relationships with the pharmaceutical industry on prescribing marketed alpha-blockers and overactive bladder (OAB) medications. We also aim to examine if the number or total value of transactions is influential.

Materials and methods: We linked the Open Payments Program database of industry payments to prescribers with Medicare Part D prescription data. We used binomial logistic regression to identify the association between receipt of industry payment and prescribing of marketed alpha-blockers (silodosin) and OAB medications (fesoterodine, solifenacin, and mirabegron). We also evaluated the impact of increasing total value and number of payments on prescribing of marketed drugs.

Results: The receipt of industry payment was associated with increased odds of prescribing the marketed drug for all included drugs: silodosin (odds ratio [OR] 34.1), fesoterodine (OR 5.9), solifenacin (OR 2.7), and mirabegron (OR 6.8) (all P <.001). We also found that increasing value of total payment and increasing frequency of payments were both independently associated with increased odds of prescribing with a dose-response effect.

Conclusion: There is a consistent association between receipt of industry payment and prescribing marketed alpha-blockers and OAB medications. Both the total value and number of transactions were associated with prescribing.

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Figures

Figure 1
Figure 1
Predicted probability of prescribing silodosin among prescribers of at least one alpha-blocker.
Figure 2
Figure 2
Predicted probability of prescribing among prescribers of at least one OAB drug. a. Fesoterodine b. Solifenacin c. Mirabegron
Figure 2
Figure 2
Predicted probability of prescribing among prescribers of at least one OAB drug. a. Fesoterodine b. Solifenacin c. Mirabegron
Figure 2
Figure 2
Predicted probability of prescribing among prescribers of at least one OAB drug. a. Fesoterodine b. Solifenacin c. Mirabegron
See this image and copyright information in PMC

References

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