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Case Reports
. 2018 Jan-Mar;11(1):75-78.
doi: 10.4103/jhrs.JHRS_65_17.

Live Birth after Rescue In vitro Maturation-intracytoplasmic Sperm Injection in Type 1 Diabetes, Polycystic Ovary Syndrome Patient Using Clomiphene-antagonist Protocol

Samundi Sankari  1 , M Elanchezhian  1 , Divya Selvamani  1 , M Nagarajan  1 , D Gopikrishnan  1
Affiliations
Case Reports

Live Birth after Rescue In vitro Maturation-intracytoplasmic Sperm Injection in Type 1 Diabetes, Polycystic Ovary Syndrome Patient Using Clomiphene-antagonist Protocol

Samundi Sankari et al. J Hum Reprod Sci. 2018 Jan-Mar.

Abstract

Infertility in patients with polycystic ovary syndrome (PCOS) associated with diabetes leads to challenging situations seeking alternative treatments. In vitro maturation (IVM) followed by intracytoplasmic sperm injection (ICSI) could overcome the challenges with promising pregnancies in such patients. In the treatment of a 32-year-old diabetic woman who also had PCOS, single immature oocyte was retrieved. Rescue IVM followed by ICSI yielded a grade 1 day 3 embryo which on transferring resulted in pregnancy and a healthy infant was delivered. Rescue IVM-ICSI could help in achieving pregnancy and live birth. Stimulation involving clomiphene and gonadotropin-releasing hormone antagonist is an effective and patient-friendly protocol for women with PCOS and diabetes and also for poor responders.

Keywords: Clomiphene; diabetes; in vitro fertilization; in vitro maturation; polycystic ovary syndrome.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Obtained germinal vesicle oocyte after denudation
Figure 2
Figure 2
MII oocyte after in vitro maturation
Figure 3
Figure 3
Two pronuclei stage
Figure 4
Figure 4
Transferred day 3 embryo
See this image and copyright information in PMC

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