Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Feb 19;10(2):e2203.
doi: 10.7759/cureus.2203.

A Comparative Review of Demographics, Incidence, and Epidemiology of Histologically Confirmed Intracranial Tumors in Brazil and Bulgaria

George S Stoyanov  1 , Jonathan S Sarraf  2 , Boyko K Matev  3 , Deyan L Dzhenkov  4 , Martina Kitanova  4 , Bogomil Iliev  5 , Peter Ghenev  4 , Anton B Tonchev  6 , Yavor Enchev  5 , Fernando Adami  7 , Luis Eduardo W De Carvalho  7
Affiliations
Review

A Comparative Review of Demographics, Incidence, and Epidemiology of Histologically Confirmed Intracranial Tumors in Brazil and Bulgaria

George S Stoyanov et al. Cureus. .

Abstract

Intracranial tumors (ICTs) attract numerous scientific teams and tremendous financial resources worldwide. These lesions of the central nervous system (CNS) can be both benign and malignant in biological behavior as well as local or metastatic in origin. We compared data from two studies on primary and metastatic ICTs from Brazil and Bulgaria, based on histopathologically confirmed ICTs from tertiary health centers. Primary ICTs significantly outweigh the frequency of metastatic ICTs. Primary ICTs represent 86.45% in Brazil and 69.17% in Bulgaria, with around 60% of their totals being malignant. There is a statistical dominance of tumors from the neuroepithelial origin, with the most common entry being glioblastoma multiforme. The second-most common primary ICT group comprises tumors of meningeal origin. Metastatic ICTs show great variance; 13.55% in Brazil and 31.38% in Bulgaria of all ICT cases being attributed to them. However, metastatic ICTs are even a more diverse group than neuroepithelial tumors, with the majority of this group comprising metastatic colorectal adenocarcinoma (almost exclusively in males), metastatic breast adenocarcinoma in females, metastatic pulmonary carcinomas (primarily from the non-small cell group with a male predominance), and metastatic melanoma with an even gender ratio.

Keywords: comparison; demographics; ethnic factors; frequency; incidence; metastatic intracranial tumors; oncology; pathology; primary intracranial tumors; statistics.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Comparison between ICTs in Brazil in Bulgaria, with benign and malignant comparison for primary ICTs in Bulgaria
ICT: intracranial tumor
See this image and copyright information in PMC

References

    1. On the concepts and history of glioblastoma multi-forme - morphology, genetics and epigenetics. Stoyanov GS, Dzhenkov DL. https://foliamedica.bg/en/english/57-ahead-of-print/current/470-on-the-c... Folia Med (Plovdiv) 2018;60:0. - PubMed
    1. Contribution of 1p 19q, 9p and 10q automated analysis by FISH to the diagnosis and prognosis of oligodendroglial tumors according to WHO 2016 guidelines. [Feb;2018 ];Michaud K, de Tayrac M, D'Astous M, et al. PLoS One. 2016 11:0. - PMC - PubMed
    1. Fuentes-Raspall R, Solans M, Roca-Barceló A, et al. Cancer Epidemiol. Vol. 50. Of Print; 2017. Descriptive epidemiology of primary malignant and non-malignant central nervous tumors in Spain: Results from the Girona Cancer Registry (1994-2013) pp. 1–8. - PubMed
    1. Brain metastases as the only manifestation of an undetected primary tumor. Nguyen LN, Maor MH, Oswald MJ. Cancer. 1998;83:2181–2184. - PubMed
    1. Brain metastases: epidemiology and pathophysiology. Gavrilovic IT, Posner JB. J Neurooncol. 2005;75:5–14. - PubMed

LinkOut - more resources