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Case Reports
. 2018 Apr 10:9:58-64.
doi: 10.1016/j.lrr.2018.04.004. eCollection 2018.

Systemic lupus erythematosus and myelofibrosis: A case report and revision of literature

F Del Porto  1 , C Tatarelli  2 , A Di Napoli  3 , M Proietta  1
Affiliations
Case Reports

Systemic lupus erythematosus and myelofibrosis: A case report and revision of literature

F Del Porto et al. Leuk Res Rep. .

Abstract

Blood cytopenia represents one of the diagnostic criteria for systemic lupus erythematosus (SLE) and may occur as the first symptom of the disease. Antibody-mediated peripheral destruction of blood cells is the main cause of cytopenia observed in patients affected by SLE, however, inflammatory anemia, nutritional deficiencies, immunosuppressive therapy and, more rarely, myelofibrosis (MF) have also been documented. In the literature, 45 cases of autoimmune MF (AIMF) and SLE have been previously reported. Here the 46 th case of a 43-year-old female with a SLE and an underhand cytopenia, with a review of the literature.

Keywords: Autoimmune myelofibrosis; Blood cytopenia; Systemic lupus erythematosus.

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Figures

Fig. 1
Fig. 1
Histology of consecutive trephine bone marrow biopsies (BMB). Pre-treatment BMB showed marked reticulin and collagenic interstitial fibrosis (MF-3) (A Haematoxylin and Eosin stain x100; B Gomori reticulin stain x100). During treatment BMB showed reduced collagenic interstitial fribrosis (MF-2) (C Haematoxylin and Eosin stain x100; D Gomori reticulin stain x100). Post treatment BMB showed regression of bone marrow fibrosis (MF-0) (E Haematoxylin and Eosin stain x100; F Gomori reticulin stain x100).
See this image and copyright information in PMC

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