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Review
. 2018 Feb 22:2018:1750368.
doi: 10.1155/2018/1750368. eCollection 2018.

Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview

Sai Sandeep Singh Rowdhwal  1   2 , Jiaxiang Chen  1   3
Affiliations
Review

Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview

Sai Sandeep Singh Rowdhwal et al. Biomed Res Int. .

Abstract

Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo.

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Figures

Figure 1
Figure 1
DEHP and its main metabolites.
See this image and copyright information in PMC

References

    1. Huang P.-C., Tien C.-J., Sun Y.-M., Hsieh C.-Y., Lee C.-C. Occurrence of phthalates in sediment and biota: relationship to aquatic factors and the biota-sediment accumulation factor. Chemosphere. 2008;73(4):539–544. doi: 10.1016/j.chemosphere.2008.06.019. - DOI - PubMed
    1. Shelby M. D. NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP) NTP-CERHR monograph. 2006;(18) - PubMed
    1. Earls A., Axford I. P., Braybrook J. H. Gas chromatography-mass spectrometry determination of the migration of phthalate plasticisers from polyvinyl chloride toys and childcare articles. Journal of Chromatography A. 2003;983(1-2):237–246. doi: 10.1016/S0021-9673(02)01736-3. - DOI - PubMed
    1. Koniecki D., Wang R., Moody R. P., Zhu J. Phthalates in cosmetic and personal care products: Concentrations and possible dermal exposure. Environmental Research. 2011;111(3):329–336. doi: 10.1016/j.envres.2011.01.013. - DOI - PubMed
    1. Dobrzyńska M. M. Phthalates - widespread occurrence and the effect on male gametes. Part 1. General characteristics, sources and human exposure. Roczniki Państwowego Zakładu Higieny. 2016;67(2):97–103. - PubMed