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. 1988 Jun 20;233(2):355-8.
doi: 10.1016/0014-5793(88)80459-9.

The ATP-driven primary Na+ pump in subcellular vesicles of Vibrio alginolyticus

P A Dibrov  1 , V P Skulachev, M V Sokolov, M L Verkhovskaya
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Free article

The ATP-driven primary Na+ pump in subcellular vesicles of Vibrio alginolyticus

P A Dibrov et al. FEBS Lett. .
Free article

Abstract

Subcellular vesicles of Vibrio alginolyticus hydrolyze ATP and accumulate Na+ in an ATP-dependent fashion. The Na+ uptake is (i) strongly stimulated by delta psi-discharging agents, i.e., the protonophorous uncoupler CCCP or valinomycin + K+ and (ii) arrested by DCCD at a concentration strongly inhibiting ATP hydrolysis. Lower concentrations of DCCD stimulate the Na+ accumulation supported by ATP hydrolysis as well as by NADH oxidation. It is concluded that there is an electrogenic DCCD-sensitive Na+-ATPase in the cytoplasmic membrane of V. alginolyticus.

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