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Clinical Trial
. 2018 Jul;40(5):379-381.
doi: 10.1097/MPH.0000000000001159.

Kidney-protective Effect of Magnesium Supplementation in Cisplatin-containing Chemotherapy for Pediatric Cancer: A Retrospective Study

Motohiro Matsui  1 , Yuya Saito  1 , Shoko Yamaoka  1 , Yuichi Yokokawa  1 , Yoshihiko Morikawa  2 , Atsushi Makimoto  1 , Yuki Yuza  1
Affiliations
Clinical Trial

Kidney-protective Effect of Magnesium Supplementation in Cisplatin-containing Chemotherapy for Pediatric Cancer: A Retrospective Study

Motohiro Matsui et al. J Pediatr Hematol Oncol. 2018 Jul.

Abstract

In total, 158 chemotherapy courses containing cisplatin for 37 pediatric cases of newly diagnosed cancer were divided into 2 groups depending on whether magnesium (Mg) supplementation was administered (Mg+: 92 courses) or not (Mg-: 66 courses). Renal impairment was defined as grade 2 or higher creatinine elevation (CE) after each chemotherapy course. The incidence of CE in the Mg+ was significantly lower than in the Mg- (9.8% vs. 22.7%; P=0.025). Multivariate analysis revealed that Mg supplementation significantly reduced the incidence of CE (odds ratio, 0.36; confidence interval, 0.13-0.99). In pediatric patients, Mg supplementation during cisplatin-containing chemotherapy was associated with less cisplatin-induced nephrotoxicity to prevent cisplatin-induced nephrotoxicity.

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