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. 2018 Jul;79(7):527-529.
doi: 10.1016/j.humimm.2018.04.012. Epub 2018 Apr 21.

HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians

Asgeir Lande  1 , Irene Andersen  2 , Torstein Egeland  3 , Benedicte A Lie  4 , Marte K Viken  2
Affiliations

HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians

Asgeir Lande et al. Hum Immunol. 2018 Jul.

Abstract

We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on a Next Generation Sequencing platform. Data were analyzed using Arlequin and Pypop software. No significant deviations from Hardy-Weinberg Equilibrium were noted at any of the loci studied. We discuss the representability for the Norwegian population and argue that the presented HLA data could serve as a Norwegian reference panel.

Keywords: HLA; HLA allele frequency; Haplotype; Reference panel.

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