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Multicenter Study
. 2018 Aug:46:55-57.
doi: 10.1016/j.jcrc.2018.03.029. Epub 2018 Apr 4.

Late organ failures in patients with prolonged intensive care unit stays

Elizabeth M Viglianti  1 , Rachel Kramer  2 , Andrew J Admon  3 , Michael W Sjoding  4 , Carol L Hodgson  5 , Rinaldo Bellomo  6 , Theodore J Iwashyna  7
Affiliations
Multicenter Study

Late organ failures in patients with prolonged intensive care unit stays

Elizabeth M Viglianti et al. J Crit Care. 2018 Aug.

Abstract

Purpose: The purpose of this study was to characterize the organ failures that develop among patients with prolonged ICU stays, defined as those who spent a minimum of 14 days in an ICU.

Methods: We retrospectively studied a cohort of consecutive patients from a university hospital who were in an ICU for a minimum of 14 days during 2014-2016. We calculated daily Sequential Organ Failure Assessment (SOFA) scores from admission to ICU day 14. The primary outcome was the number of new late organ failures, defined as occurring on ICU day 4 through 14.

Results: In a retrospective cohort of 3777 consecutive patients in six ICUs, 50 patients had prolonged ICU stays. Of those 50, new cardiovascular failure occurred in 24 (62%) on day 4 or later; persistent mechanical ventilation was present in only 28 (56%).

Conclusions: Strategies aiming to reduce the development of new late organ failures may be a novel target for preventing persistent critical illness.

Keywords: Chronic critical illness; Outcomes; Persistent critical illness; Prolonged ICU stay; Prolonged mechanical ventilation.

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References

    1. Iwashyna TJ, Hodgson CL, Pilcher D, et al. Persistent critical illness characterised by Australian and New Zealand ICU clinicians. Crit Care Resusc. 2015;17:153–158. - PubMed
    1. Iwashyna TJ, Hodgson CL, Pilcher D, et al. Timing of onset and burden of persistent critical illness in Australia and New Zealand: a retrospective, population-based, observational study. The Lancet Respiratory medicine. 2016;4:566–573. - PubMed
    1. Vincent JL, de Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26:1793–1800. - PubMed
    1. Chen LM, Martin CM, Morrison TL, et al. Interobserver variability in data collection of the APACHE II score in teaching and community hospitals. Crit Care Med. 1999;27:1999–2004. - PubMed
    1. Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283–1297. - PubMed

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